A vaccine against human papillomavirus — the most common sexually transmitted infection and the cause of almost all cervical cancer — is dramatically reducing the prevalence of HPV in teenage girls.

The first vaccine against HPV, Merck's Gardasil, was approved by the Food and Drug Administration in 2006. Cerverix, from GlaxoSmithKline, was approved in 2009.

A new report by the Upjohn Institute for Employment Research finds positive academic effects from the Kalamazoo County Ready4s program.

I visited Toy Fair in New York City hunting for ideas for our summer series about kids' culture. One of the big takeaways was the increasing popularity of construction games such as Legos. Sales shot up nearly 20 percent last year. Now, it seems, every major toy manufacturer is scrambling to add new games geared toward kids building things.

Author Daniel Handler, who writes under the pen name Lemony Snicket, is known for his dry wit and matter-of-fact take on the mysterious and macabre. In his A Series of Unfortunate Events books and Who Could That Be at This Hour?, the protagonists confront twisted characters and dastardly villains.

In his latest children's book, he takes on the dark itself, with the story of a young boy who confronts his biggest fear.

Transcript

NEAL CONAN, HOST:

It's Wednesday, and time to read from your comments. James in Laurel Hill, Florida, emailed during our conversation about research into rare diseases: I would like to affirm the comment made by your guest about rare disease research leading to help for more common diseases. He wrote: My nephew has brittle bone disease. Some aspects of his treatment have been used to help mend broken bones in accident victims. So research into rare disorders can definitely lead to treatment for others.

Transcript

NEAL CONAN, HOST:

This is TALK OF THE NATION. I'm Neal Conan in Washington. With school out, many college - and even some high school students - will spend the summer working as interns. It's a chance to beef up their resumes, gain on-the-job experience and make valuable contacts. Last week, a federal district court judge in New York issued a ruling that could change the system.

Transcript

NEAL CONAN, HOST:

This is TALK OF THE NATION. I'm Neal Conan in Washington. The speaker clamps the Hastert Rule on immigration reform. Three Republican senators now support gay marriage. And the Bay State Senate race goes into its last week. It's Wednesday and time for a penultimate edition of the political junkie.

(SOUNDBITE OF ARCHIVED RECORDINGS)

PRESIDENT RONALD REAGAN: There you go again.

VICE PRESIDENT WALTER MONDALE: When I hear your new ideas, I'm reminded of that ad: Where's the beef?