All Things Considered

Weekdays from 4 to 6 p.m.
Melissa Block and Robert Siegel

In-depth reporting and transformed the way listeners understand current events and view the world. Every weekday, hear two hours of breaking news mixed with compelling analysis, insightful commentaries, interviews, and special - sometimes quirky - features.

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Shots - Health News
6:01 pm
Thu March 27, 2014

How Being Ignored Helped A Woman Discover The Breast Cancer Gene

Mary-Claire King says obscurity gave her the freedom to spend years looking for breast cancer genes.
Mary Levin/University of Washington

Originally published on Sun March 30, 2014 9:17 am

Back in the 1970s, a geneticist named Mary-Claire King decided she needed to figure out why women in some families were much more likely to get breast cancer.

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Middle East
5:27 pm
Thu March 27, 2014

President Prepares To Meet King As U.S.-Saudi Divisions Deepen

Originally published on Thu March 27, 2014 7:03 pm

Transcript

ROBERT SIEGEL, HOST:

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Politics
5:27 pm
Thu March 27, 2014

Voting Rights Fight Takes New Direction

An election official checks a voter's photo identification at an early-voting polling site in Austin, Texas.
Eric Gay AP

Originally published on Thu March 27, 2014 7:03 pm

It's that time again, when primary voters start casting their ballots for the midterm elections. As in recent years, voters face new rules and restrictions, including the need in 16 states to show a photo ID.

But this year, some voting rights activists say they're seeing a change — fewer new restrictions and, in some places, even a hint of bipartisanship.

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Book Reviews
5:27 pm
Thu March 27, 2014

Book Review: 'How To Dance As The Roof Caves In'

Originally published on Thu March 27, 2014 6:25 pm

Transcript

ROBERT SIEGEL, HOST:

Making poetry out of something as messy as the recent housing crisis may sound like a tall order, but Nick Lantz has done it. The collection is called "How to Dance as the Roof Caves In." Our reviewer, Tess Taylor says calls it biting but tender.

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Shots - Health News
4:31 pm
Thu March 27, 2014

Custom Chromo: First Yeast Chromosome Built From Scratch

The research team used yeast chromosome No. 3 as the model for their biochemical stitchery. Pins and white diamonds in the illustration represent "designer changes" not found in the usual No. 3; yellow stretches represent deletions.
Lucy Reading-Ikkanda

Originally published on Thu March 27, 2014 7:03 pm

Using the labor of dozens of undergraduate students, scientists have built a customized yeast chromosome from scratch.

It's a milestone in the rapidly growing field of synthetic biology, where organisms can be tailored for industrial use. In this case, the near-term goal is to understand the genetics of yeast, and eventually the genetics of us.

This was quite an undertaking. Yeast have about 6,000 genes packed in 16 tidy bundles called chromosomes. Each chromosome is an enormous molecule of DNA packed in proteins.

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